Estradiol and norgestimate
Generic name: estradiol and norgestimate [ ES-tra-DYE-ol-and-nor-JES-ti-mate ]
Brand names: Prefest, Ortho-Prefest
Dosage form: oral tablet (biphasic)
Drug class:Sex hormone combinations
What is estradiol and norgestimate?
Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body.
Norgestimate is a form of progesterone, a female hormone important for regulating ovulation and menstruation.
Estradiol and norgestimate is a combination medicine used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women.
Estradiol and norgestimate may also be used for purposes not listed in this medication guide.
Warnings
You should not use estradiol and norgestimate if you have had a hysterectomy, or if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, if you will have major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.
Do not use if you are pregnant.
Estradiol and norgestimate may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.
Using this medicine can increase your risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries. Estradiol and norgestimate should not be used to prevent heart disease, stroke, or dementia.
Before taking this medicine
You should not use this medicine if you are allergic to estradiol or norgestimate, if you have had a hysterectomy, or if you have:
unusual vaginal bleeding that has not been checked by a doctor;
liver disease;
a history of heart attack, stroke, or blood clot; or
a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.
Do not use estradiol and norgestimate if you are pregnant. Tell your doctor right away if you become pregnant during treatment.
Using this medicine can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you ar...
