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Estradiol Vaginal Insert
  • Professionals
  • FDA PI

Estradiol Vaginal Insert

Dosage form: vaginal insert
Drug classes:Estrogens, Miscellaneous vaginal agents

Medically reviewed by Drugs.com. Last updated on Apr 21, 2022.

WARNING: ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, BREAST CANCER and PROBABLE DEMENTIA

Estrogen-Alone Therapy

Endometrial Cancer

There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens. Adding a progestin to estrogen therapy has been shown to reduce the risk of endometrial hyperplasia, which may be a precursor to endometrial cancer. Adequate diagnostic measures, including directed or random endometrial sampling when indicated, shou...