Estroplan

Generic name: cloprostenol sodium injection
Dosage form: FOR ANIMAL USE ONLY

Prostaglandin Analogue For Cattle

Equivalent to 250 mcg cloprostenol/mL

CAUTION: Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.

DESCRIPTION:
Estroplan (cloprostenol sodium) injection is a synthetic prostaglandin analogue structurally related to prostaglandin F2α (PGF2α). Each mL of the colorless aqueous solution contains 263 mcg of cloprostenol sodium (equivalent to 250 mcg of cloprostenol), chlorocresol 1.0 mg as a bactericide, citric acid anhydrous 0.66 mg, sodium citrate 5.03 mg, sodium chloride 6.76 mg. The pH is adjusted, as necessary, with sodium hydroxide or citric acid.

ACTION:
Estroplan injection causes functional and morphological regression of the corpus luteum (luteolysis) in cattle. In normal, nonpregnant cycling animals this effect on the life span of the corpus luteum usually results in estrus 2 to 5 days after treatment. In animals with prolonged luteal function (pyometra, mummified fetus, and luteal cysts) the induced luteolysis usually results in resolution of the condition and return to cyclicity. Pregnant animals may abort depending on the stage of gestation.

INDICATIONS:
For intramuscular use to induce luteolysis in beef and dairy cattle. The luteolytic action of Estroplan injection can be utilized to manipulate the estrous cycle to better fit certain management practices, to terminate pregnancies resulting from mismatings and to treat certain conditions associated with prolonged luteal function.

RECOMMENDED USES:
Unobserved or Non-detected Estrus
Cows which are not detected in estrus, although ovarian cyclicity continues, can be treated with Estroplan if a mature corpus luteum is present. Estrus is expected to occur 2 to 5 days following injection, at which time animals may be inseminated. Treated cattle should be inseminated at the usual time following detection of estrus. If estrus detection is not desirable or possible, treated animals may be inseminated twice at about 72 and 96 hours post injection.

Pyometra Or Chronic Endometritis
Damage to the reproductive tract at calving or post partum retention of the placenta often leads to infection and inflammation of the uterus (endometritis). Under certain circumstances, this may progress into chronic endometritis with the uterus becoming distended with purulent matter. This condition, commonly referred to as pyometra, is characterized by a lack of cyclical estrus behavior and the presence of a persistent corpus luteum. Induction of luteolysis with Estroplan usually results in evacuation of the uterus and a return to normal cyclical activity within 14 days after..