Ethacrynic Sodium Injection

Dosage form: powder, for intravenous solution
Drug class:Loop diuretics

Medically reviewed by Drugs.com. Last updated on Aug 1, 2020.

Ethacrynic acid is a potent diuretic which, if given in excessive amounts, may lead to profound diuresis with water and electrolyte depletion. Therefore, careful medical supervision is required, and dose and dose schedule must be adjusted to the individual patient’s needs (see DOSAGE AND ADMINISTRATION).

Ethacrynic Sodium Injection Description

Ethacrynic acid is an unsaturated ketone derivative of an aryloxyacetic acid. It is designated chemically as [2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy] acetic acid, and has a molecular weight of 303.14. Ethacrynic acid is a white, or practically white, crystalline powder, very slightly soluble in water, but soluble in most organic solvents such as alcohols, chloroform, and benzene. Its empirical formula is C13H12Cl2O4 and its structural formula is:

Ethacrynate sodium, the sodium salt of ethacrynic acid, is soluble in water at 25°C to the extent of about 7 percent.

Solutions of the sodium salt are relatively stable at about pH 7 at room temperature for short periods, but as the pH or temperature increases the solutions are less stable. The molecular weight of ethacrynate sodium is 325.12. Its empirical formula is C13H11Cl2NaO4 and its structural formula is:

Ethacrynic acid is supplied as 25 mg tablets for oral use. The tablets contain the following inactive ingredients: colloidal silicon dioxide, lactose, magnesium stearate, starch and talc.

Intravenous ethacrynate sodium is a sterile freeze-dried powder and is supplied in a vial containing:

Ethacrynate sodium equivalent
to ethacrynic acid . . . . . . . . . 50.0 mg

Inactive ingredient:

Mannitol . . . . . . . . . . . . . . . . 62.5 mg

Ethacrynic Sodium Injection - Clinical Pharmacology

Pharmacokinetics and Metabolism

Ethacrynic acid acts on the ascending limb of the loop of Henle and on the proximal and distal tubules. Urinary output is usually dose dep..