Fedratinib
Generic name: fedratinib [ fed-RA-ti-nib ]
Brand name: Inrebic
Dosage form: oral capsule (100 mg)
Drug class:Multikinase inhibitors
What is fedratinib?
Fedratinib is used to treat myelofibrosis in adults.
Myelofibrosis is a rare type of bone marrow cancer that affects your body's ability to produce blood cells.
Fedratinib may also be used for purposes not listed in this medication guide.
Warnings
Some people using fedratinib have developed vitamin B1 deficiency that resulted in serious and sometimes fatal brain damage. Your vitamin B1 levels will need to be checked before and during treatment, and you may need to take a vitamin B1 supplement.
Get emergency medical help if you have symptoms such as drowsiness, confusion, memory problems, vision problems, unusual eye movements, or problems with coordination and muscle movement.
Call your doctor if you are sick with vomiting or diarrhea even while taking medications to prevent these side effects.
Before taking this medicine
Tell your doctor if you have ever had:
low levels of platelets or red blood cells;
kidney disease; or
if you have been taking ruxolitinib (Jakafi).
It is not known whether fedratinib will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
You should not breastfeed while using this medicine, and for at least 1 month after your last dose.
How should I take fedratinib?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
You may take fedratinib with or without food. Take with a high-fat meal if fedratinib upsets your stomach.
Your vitamin B1 (thiamine) levels will need to be checked before and during treatment with fedratinib. You may need to take a vitamin B1 supplement.
You may be given other medications to help prevent nausea, vomiting, and diarrhea. Keep using these medicines for as long as your doctor has prescribed.
Some people using fedratinib have developed vitamin B1 deficiency that resulted in serious and sometimes fatal brain damage. Your vitamin B1 levels will need to be checked before and during treatment with fedratinib. You may...
