Fenofibric Acid/Fenofibrate

Class: Fibric Acid Derivatives
VA Class: CV350
Chemical Name: 2-[p-(p-chlorobenzoyl)phenoxy]-2-methylpropionate
Molecular Formula: C₂₀H₂₁ClO₄
CAS Number: 42017-89-0
Brands: Antara, Fenoglide, Fibricor, Lipofen, TriCor, Triglide, Trilipix

Medically reviewed by Drugs.com on Jul 26, 2021. Written by ASHP.

Introduction

Fenofibric acid (active moiety) and fenofibrate are antilipemic agents; fibric acid derivatives.

Uses for Fenofibric Acid/Fenofibrate

Dyslipidemias

Adjuncts to dietary therapy to decrease elevated serum total and LDL-cholesterol, triglyceride, and apolipoprotein B (apo B) concentrations, and to increase HDL-cholesterol concentrations in the management of primary hypercholesterolemia and mixed dyslipidemia, including heterozygous familial hypercholesterolemia and other causes of hypercholesterolemia. Additive antilipemic effects when used concomitantly with other antilipemic agents (e.g., colesevelam, ezetimibe).

Adjuncts to dietary therapy in the management of severe hypertriglyceridemia. Efficacy in reducing risk of pancreatitis in patients with marked elevations in triglyceride concentrations (i.e., >2000 mg/dL) not established.

Effects on cardiovascular morbidity and mortality or noncardiovascular mortality not established. (See Effects on Morbidity and Mortality under Cautions.)

AHA/ACC cholesterol management guideline states that lifestyle modification is the foundation of cardiovascular risk reduction. If pharmacologic therapy is needed, statins are first-line drugs of choice because of their demonstrated benefits in reducing risk of atherosclerotic cardiovascular disease (ASCVD). Nonstatin drugs may be considered as adjunctive therapy in certain high-risk patients, but other drugs (e.g., ezetimibe) are generally recommended. Although fibrates have mild LDL-lowering effects, randomized controlled studies do not support their use as add-on therapy to statins.

If fibrate therapy is necessary in a ...