Fluocinolone (EENT)

Class: Corticosteroids
Chemical Name: (6α,11β,16α)-6,9-Difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione
Molecular Formula: C₂₄H₃₀F₂O₆
CAS Number: 67-73-2
Brands: Retisert

Medically reviewed by Drugs.com on May 23, 2022. Written by ASHP.

Introduction

Synthetic fluorinated corticosteroid.

Uses for Fluocinolone (EENT)

Uveitis

Management of chronic noninfectious uveitis affecting the posterior segment of the eye (designated an orphan drug by FDA for this use).

Fluocinolone (EENT) Dosage and Administration

Administration

Ophthalmic Administration

Surgically implant intravitreally through a pars plana incision into posterior segment of eye.

Maintain aseptic technique prior to and during the procedure to ensure sterility of the surgical field and implants. Do not resterilize implants by any method.

Handle implants only by the suture tab to avoid damaging the implant; damage may increase rate of drug release.

Avoid simultaneous implantation into both eyes in order to minimize risk of bilateral postoperative infections.

Following depletion of fluocinolone acetonide from the implant, may remove the implant and replace with a new one to continue therapy.

During implantation and explantation, avoid applying sheer forces on the implant that could disengage the silicone cup reservoir from the suture tab.

Dosage

Available as fluocinolone acetonide; dosage expressed in terms of the salt.

Pediatric Patients

Uveitis

Ophthalmic

Children ≥12 years of age: 0.59 mg (1 implant) in affected eye(s) approximately every 30 months.

Adults

Uveitis

Ophthalmic

0.59 mg (1 implant) in affected eye(s) approximately every 30 months.

Cautions for Fluocinolone (EENT)

Contraindications

• Viral diseases of the cornea and conjunctiva (e.g., epithelial herpes simplex keratitis [dendritic keratitis], vaccinia, varicella).

• Mycobacterial infection of the eye.

• Fungal diseases of ocular structures.

• Known or suspected hypersensitivity to fluocinolone acetonide, other corticosteroids, or any ingredient in the formulation.

Warnings/Precautions

Warnings

Surgical Complications

Potential complications accompanying insertion of the implant may include cataract formation, choroidal or retinal detachment, temporary decrease in visual acuity, endophthalmitis, hypotony, incr...