Fluticasone (Systemic, Oral Inhalation)

Class: Adrenals
VA Class: RE101
Molecular Formula: C₂₅H₃₁F₃O₅S
CAS Number: 80474-14-2
Brands: Advair HFA (combination), Flovent HFA

Medically reviewed by Drugs.com on Nov 9, 2021. Written by ASHP.

Introduction

Synthetic trifluorinated glucocorticoid.

Uses for Fluticasone (Systemic, Oral Inhalation)

Asthma

Fluticasone used for long-term prevention of bronchospasm in patients with asthma.

In corticosteroid-dependent patients, fluticasone may permit a substantial reduction in the daily maintenance dosage of the systemic corticosteroid and gradual discontinuance of corticosteroid maintenance dosages.

Fluticasone/salmeterol fixed combination is used only in patients with asthma not responding adequately to long-term asthma controller therapy (e.g., inhaled corticosteroids) or whose disease severity clearly warrants initiation of treatment with both an inhaled corticosteroid and a long-acting β₂-adrenergic agonist.

Once asthma control achieved and maintained, assess patient at regular intervals and step down therapy (e.g., discontinue fluticasone/salmeterol), if possible without loss of asthma control, and maintain patient on long-term asthma controller therapy (e.g., inhaled corticosteroids).

Do not use fluticasone/salmeterol in patients with asthma adequately controlled on low or medium dosage of inhaled corticosteroids.

COPD

Fixed combination with salmeterol as the oral inhalation powder (Advair Diskus) is used for maintenance treatment of airflow obstruction in patients with COPD, including chronic bronchitis and/or emphysema; also used to reduce exacerbations of COPD in patients with a history of exacerbations.

Fluticasone/salmeterol is not indicated for relief of acute bronchospasm.

Fluticasone (Systemic, Oral Inhalation) Dosage and Administration

General

• Adjust dosage carefully ...