Foltrexyl

Generic name:folic acid and vitamin d
Dosage form: tablet
Drug class:Vitamin and mineral combinations

Medically reviewed by Drugs.com. Last updated on Oct 1, 2020.

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. Read further information about unapproved drugs.

Foltrexyl Description

Foltrexyl™ is an orally administered prescription folate product for the dietary management of patients with unique
nutritional needs requiring increased folate levels and Vitamin D supplementation due to Vitamin D deficiency.

Foltrexyl™ should be administered under the supervision of
a licensed medical practitioner.

Each tablet contains:
Folate (as folic acid)……………………..1700 mcg DFE†
(1000 mcg folic acid)
Vitamin D3 (cholecalciferol)………....125 mcg (5000 IU)

Each tablet contains the following inactive ingredients: lactose monohydrate, microcrystalline cellulose, sodium
starch glycolate, stearic acid, magnesium stearate.

† Dietary Folate Equivalent

INDICATIONS AND DOSAGE

Foltrexyl™ is indicated for dietary management of patients with unique nutritional needs requiring increased folate
levels and Vitamin D supplementation.

Foltrexyl™ can be taken by women of childbearing age, pregnant women, and lactating and nonlactating mothers.

Foltrexyl - Clinical Pharmacology

The in vivo synthesis of the major biologically active metabolites of vitamin D occurs in two steps. The first hydroxylation of ergocalciferol takes place in the liver (to 25-hydroxyvitamin D) and the second in the kidneys (to 1,25-dihydroxyvitamin D). Vitamin D metabolites promote the active absorption of calcium and phosphorus by the small intestine, thus elevating serum calcium and phosphate levels sufficiently to permit bone mineralization. Vitamin D metabolites also mobilize calcium and phosphate from bone and probably increase the reabsorption of calcium and perhaps also of phosphate by the renal tubules.

There is a time lag of 10 to 24 hours between the administration of vitamin D and the initiation of its action in the body due to the necessity of synthesis of the active metabolites in the liver and kidneys. Parathyroid hormone is responsible for the regulation of this metabolism in the kidn