Gadoteridol (Intravenous)
Medically reviewed by Drugs.com. Last updated on Apr 27, 2022.
Gadolinium-based contrast agents (GBCAs) increase the risk for nephrogenic systemic fibrosis (NSF) in patients with impaired elimination of the drugs. . Avoid use of GBCAs in these patients unless the diagnostic information is essential and not available with non-contrast enhanced MRI or other modalities. NSF may result in fatal or debilitating systemic fibrosis affecting the skin, muscle, and internal organs. The risk for NSF appears highest among patients with chronic, severe renal insufficiency (GFR less than 30 mL/min/1.73 m(2)), or acute kidney injury. Screen patients for acute kidney injury and other conditions that may reduce renal function. For patients at risk for chronically reduced renal function (eg, age greater than 60 years, hypertension, or diabetes), estimate the GFR through laboratory testing. For patients at highest risk for NSF, do not exceed the recommended gadoteridol dose and allow a sufficient period of time for elimination of the drug from the body prior to readministration .
Commonly used brand name(s)
In the U.S.
- Prohance
Available Dosage Forms:
- Solution
Therapeutic Class: Radiological Non-Ionic Contrast Media
Uses for gadoteridol
Gadoteridol injection is a magnetic resonance imaging (MRI) contrast agent used to help create a clear picture of the body during an MRI scan. MRI scans use magnets and computers to create images or “pictures” of certain areas of the body. Unlike x-rays, MRI scans do not involve radiation. Gadoteridol is a gadolinium-based contrast agent (GBCA) that is given by injection before an MRI to help diagnose problems in the brain, spine, head, or neck.
Gadoteridol is to be given only by or under the direct supervision of your doctor.
Before using gadoteridol
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For gadoteridol, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to gadoteridol or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of gadoteridol injection in newborns to children 17 years of age. Safety and efficacy have been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of gadoteridol injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution for patients receiving gadoteridol.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two dif..
