Class: Nucleosides and Nucleotides
VA Class: AM800
Chemical Name: 2-Amino-1,9-dihydro-9-[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one sodium salt
CAS Number: 84245-13-6
Brands: Cytovene
Warning
Hematologic toxicity (e.g., granulocytopenia, anemia, thrombocytopenia, pancytopenia) reported in patients receiving ganciclovir.
Based on animal data and limited human data, may cause temporary or permanent inhibition of spermatogenesis in males and suppression of fertility in females.
Based on animal studies, has the potential to cause birth defects in humans.
Based on animal studies, has the potential to cause cancers in humans.
Introduction
Antiviral; nucleoside analog of guanine; active against herpesviruses.
Uses for Ganciclovir Sodium
Cytomegalovirus (CMV) Retinitis
Initial treatment (induction therapy) and maintenance therapy (secondary prophylaxis) of CMV retinitis in immunocompromised patients, including HIV-infected adults. Also used for management of CMV retinitis in HIV-infected pediatric patients†.
Like other antivirals, ganciclovir is not a cure for CMV retinitis; stabilization or improvement of ocular manifestations may occur, but relapse and/or progression of CMV retinitis possible during or following ganciclovir therapy.
Retinitis is the most common clinical manifestation of CMV end-organ disease in HIV-infected patients; ideally should be managed in consultation with an ophthalmologist familiar with diagnosis and treatment of retinal diseases.
Select antiviral regimen for initial treatment of CMV retinitis in HIV-infected individuals based on location and severity of CMV retinal lesions, severity of underlying immunosuppression, concomitant drug therapy, and patient’s ability to adhere to the treatment regimen. Select antiviral regimen for mainte...
