Dosage form: tablet
Drug class:Sulfonylureas
Medically reviewed by Drugs.com. Last updated on Jan 1, 2022.
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Glipizide Tablets Description
Glipizide is an oral blood-glucose-lowering drug of the sulfonylurea class.
The Chemical Abstracts name of glipizide is 1-cyclohexyl-3-[[p-[2-(5-methylpyrazine-carboxamido)ethyl]phenyl]sulfonyl]urea. The molecular formula is C 21H 27N 5O 4S; the molecular weight is 445.55; the structural formula is shown below:
Glipizide is a whitish, odorless powder with a pKa of 5.9. It is insoluble in water and alcohols, but soluble in 0.1 N NaOH; it is freely soluble in dimethylformamide. Glipizide Tablets, USP for oral use are available in 5 and 10 mg strengths.
Inert ingredients are: anhydrous lactose; colloidal silicon dioxide; magnesium stearate; sodium starch glycolate.
Meets USP Dissolution Test 2.
Glipizide Tablets - Clinical Pharmacology
Mechanism of Action
The primary mode of action of glipizide in experimental animals appears to be the stimulation of insulin secretion fr...
