Goserelin

Class: Gonadotropins
VA Class: AN500
Chemical Name: 2-(Aminocarbonyl)hydrazide-6-[O-(1,1-dimethylethyl)-d-serine]-10-deglycinamide luteinizing hormone-releasing factor (pig)
Molecular Formula: C₅₉H₈₄N₁₈O₁₄
CAS Number: 65807-02-5
Brands: Zoladex

Medically reviewed by Drugs.com on Jan 11, 2021. Written by ASHP.

Introduction

Synthetic analog of gonadotropin-releasing hormone (GnRH, luteinizing hormone-releasing hormone, gonadorelin); used as an antineoplastic agent and for its endocrine effects.

Uses for Goserelin

Prostate Cancer

Palliative treatment of advanced prostate cancer. Considered one of several first-line options for hormonal therapy; other options include orchiectomy, estrogens, and antiandrogens.

In clinical studies, goserelin (3.6 mg every 4 weeks) was as effective as orchiectomy. Clinical outcome in patients receiving goserelin 10.8 mg every 12 weeks expected to be similar to that of patients receiving goserelin 3.6 mg every 4 weeks.

Also used as an adjunct to radiation therapy in patients with stage III [C]) prostate cancer.

Treatment of locally confined stage T2b-T4 (B2-C) prostate cancer in conjunction with flutamide and radiation therapy.

Endometriosis

Palliative treatment of endometriosis. Experience with goserelin has been limited to women ≥18 years of age who received consecutive therapy (3.6 mg every 4 weeks) for 6 months.

Breast Cancer

Palliative treatment of advanced breast cancer in premenopausal and perimenopausal women.

Use of ovarian suppression in combination with endocrine therapy (i.e., anastrozole, exemestane, letrozole, tamoxifen)† as adjuvant therapy† in premenopausal women with early-stage hormone receptor-positive breast cancer† may be considered a reasonable choice (accepted).

Dysfunctional Uterine Bleeding

Used as an endometrial-thinning agent prior to endometrial ablation procedures for the treatment of dysfunctional uterine bleeding.

Goserelin Dosage and Administration

General

Determine serum testosterone concentrations periodically in patients with prostate cancer in whom the anticipated clinical or biochemical response to goserelin has not been achieved.

Reduction in serum prostate specific antigen (PSA) concentrations may provide information about duration of progression-free status in men with prostate cancer. Do not rely solely on PSA concentrations to monitor response because decreases in PSA concentration may occur independent of tumor response.

Administration

Sub-Q

Administered as a biodegradable implant into the anterior abdominal wall below the navel line.

Implants containing goserelin 3.6 mg are administered every 4 weeks.

Implants containing goserelin 10.8 mg are administered every 12 weeks.

Adherence to the recommended schedule recommended; a delay of a few days is permitted.

The implant may be located by ultrasound in the event that it needs to be removed.

Consult the ma...