HC Pram Cream
Generic name:hydrocortisone acetate and pramoxine
Dosage form: cream
Drug class:Anorectal preparations
Medically reviewed by Drugs.com. Last updated on Nov 22, 2021.
Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.
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HC Pram Cream Description
Topical corticosteroids are anti-inflammatory and anti-pruritic agents.
INGREDIENTS
River’s Edge HC Pram 2.5% Cream – 2.5% Hydrocortisone Acetate, 1% Pramoxine HCl
Contains hydrocortisone acetate 25mg w/w and pramoxine hydrochloride 10mg
ACTIVE INGREDIENTS:
HYDROCORTISONE ACETATE 2.5%
PRAMOXINE HCl 1%
INACTIVE INGREDIENTS: CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL, CETEARETH-20, CETEARYL ALCOHOL, DIMETHICONE, GLYCERIN, PHENOXYETHANOL, PENTYLENE GLYCOL, PURIFIED WATER, STEARIC ACID, STEARYL ALCOHOL, TETRASODIUM EDTA.
River’s Edge HC Pram 1% Cream – 1% Hydrocortisone Acetate, 1% Pramoxine HCl
Contains hydrocortisone acetate 10mg w/w and pramoxine hydrochloride 10mg
ACTIVE INGREDIENTS:
HYDROCORTISONE ACETATE 1%
PRAMOXINE HCl 1%
INACTIVE INGREDIENTS: CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL, CETEARETH-20, CETEARYL ALCOHOL, DIMETHICONE, GLYCERIN, PHENOXYETHANOL, PENTYLENE GLYCOL, PURIFIED WATER, STEARIC ACID, STEARYL ALCOHOL, TETRASODIUM EDTA.
HC Pram Cream - Clinical Pharmacology
Topical corticosteroids share anti-inflammatory, anti-pruritic and vasoconstrictive actions.
The mechanism of anti-inflammatory activity of topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinicl efficacies of the topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.
Pramoxine hydrochloride is a topical anesthetic agent which provides temporary relief from itching and pain. It acts by stabilizing the neuronal membrane of nerve endings with which it comes into contact.
PHARMACOKINETICS
The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal ba
