Hectorol Injection

Generic name:doxercalciferol
Dosage form: injection, solution
Drug class:Vitamins

Medically reviewed by Drugs.com. Last updated on Nov 22, 2021.

Indications and Usage for Hectorol Injection

• HECTOROL capsules are indicated for the treatment of secondary hyperparathyroidism in adult patients with Stage 3 or Stage 4 chronic kidney disease (CKD) and adult patients with CKD on dialysis.
• Hectorol Injection is indicated for the treatment of secondary hyperparathyroidism in adult patients with CKD on dialysis.

Hectorol Injection Dosage and Administration

Prior to Initiation of HECTOROL Capsules or Injection

• Ensure serum calcium is not above the upper limit of normal before initiating treatment with HECTOROL capsules or injection [see Warnings and Precautions (5.1)].

Dosage Recommendations for HECTOROL Capsules in Patients with Stage 3 or 4 CKD

• Initiate HECTOROL capsules at a dose of 1 mcg orally once daily.
• Target the maintenance dose of HECTOROL to intact parathyroid hormone (PTH) levels within the desired therapeutic range and serum calcium within normal limits.
• Monitor serum calcium, phosphorus, and intact PTH levels at least every two weeks for 3 months after initiation of therapy or dose adjustment, then monthly for 3 months, and every 3 months thereafter.
• Titrate the dose of HECTOROL capsules based on intact PTH. The dose may be increased at 2-week intervals by 0.5 mcg to achieve the desired therapeutic range of intact PTH. The maximum recommended dose of HECTOROL capsules is 3.5 mcg administered once daily. Prior to raising the dose, ensure serum calcium is within normal limits.
• Suspend or decrease the dose if intact PTH is persistently and abnormally low to reduce the risk of adynamic bone disease [see Warnings and Precautions (5.4)] or if serum calcium is consistently above the normal range to reduce the risk of hypercalcemia