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HumuLIN R KwikPen (Concentrated) U-500
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HumuLIN R KwikPen (Concentrated) (U-500)

Generic name:insulin regular, concentrated (U-500)IN-soo-lin ]
Brand names: HumuLIN R (Concentrated), HumuLIN R KwikPen (Concentrated)
Drug class:Insulin

Medically reviewed by Drugs.com on Mar 28, 2022. Written by Cerner Multum.

What is concentrated (U-500) insulin?

Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Concentrated (U-500) insulin is a long-acting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. U-500 insulin is five times more concentrated than regular U-100 insulin.

U-500 insulin is used to improve blood sugar control in adults and children with diabetes mellitus who have significant daily insulin needs (more than 200 units per day).

U-500 insulin may also be used for purposes not listed in this medication guide.

Warnings

Never share an injection pen, cartridge, or syringe with another person, even if the needle has been changed.

Before taking this medicine

You should not use HumuLIN R KwikPen (Concentrated) if you are allergic to insulin, or if you are having an episode of hypoglycemia (low blood sugar).

Tell your doctor if you have ever had:

  • liver or kidney disease; or

  • low levels of potassium in your blood (hypokalemia).

Tell your doctor if you also take pioglitazone or rosiglitazone (sometimes contained in combinations with glimepiride or metformin). Taking certain oral diabetes medicines while you are using insulin may increase your risk of serious heart problems.

Tell your doctor if you are pregnant or breastfeeding.

Follow your doctor's instructions about using insulin if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

How should I use U-500 insulin?

U-500 insulin is concentrated and co...