Hyalovet
Generic name: hyaluronate sodium liquid
Dosage form: FOR ANIMAL USE ONLY
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For intra-articular administration in horses only
Caution:
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Description:
Hyaluronic acid is the prototype of a wide range of saccharide biopolymers (glycosaminoglycans or mucopolysaccharides) consisting of repeating disaccharide units of N-acetyl-D-glucosamine and D-glucuronic acid linked by beta 1-3 and beta 1-4 glycosidic bonds. A component of all mammalian connective tissue, hyaluronic acid confers viscoelastic and lubricating properties to synovial fluid1 and structural integrity to cartilage matrix2. As a therapeutic agent, hyaluronic acid injected into arthritic joints has been shown, in a variety of animal model systems including horses3, to improve joint function and to activate tissue repair processes in articular cartilage.
Hyalovet (hyaluronate sodium) is clear, colorless, viscous solution of a specific fraction of highly purified hyaluronic acid obtained by a molecular filtration procedure from biological material (rooster combs). The specific hyaluronic acid fraction from which Hyalovet is made has a high degree of molecular definition with an average molecular weight of 500,000-730,000 D.
Each filled 2 mL glass syringe or 2 mL glass vial contains:
Hyaluronate sodium.....20.0 mg
Sodium chloride.....17.0 mg
Monobasic sodium phosphate.....0.1 mg
Dibasic sodium phosphate.....1.2 mg
Water for injection.....q.s., 2 mL
Indications:
Hyalovet is indicated for the intra-articular treatment of carpal or fetlock joint dysfunction in horses due to acute or chronic, non-infectious synovitis associated with equine osteoarthritis.
Dosage and Administration:
The recommended dose of Hyalovet (hyaluronate sodium) is 2 mL (20 mg hyaluronate sodium) in small or medium sized joints (carpus, fetlock) given by intra-articular injection. More than one joint may be treated at the same time. If necessary, the injection may be repeated after one or more weeks, but not to exceed 2 injections per week for a total of 4 weeks.
Hyalovet should be injected using strict aseptic technique. Excess synovial fluid should be removed prior to injection.
For best results horses should be given two days of rest or limited exercise before resuming normal training.
