Hyaluronidase and rituximab
Generic name: hyaluronidase and rituximab [ HYE-al-ure-ON-i-dase ]
Brand name: Rituxan Hycela
Dosage form: subcutaneous solution (23,400 units-1400 mg/11.7 mL; 26,800 units-1600 mg/13.4 mL)
Drug class:CD20 monoclonal antibodies
What is hyaluronidase and rituximab?
Hyaluronidase and rituximab is a combination medicine used to treat follicular lymphoma, diffuse large B-cell lymphoma, or chronic lymphocytic leukemia.
Hyaluronidase and rituximab is sometimes used together with other cancer medicines.
This combination medicine is usually given only after you have received at least 1 injection of rituximab alone.
Hyaluronidase and rituximab may also be used for purposes not listed in this medication guide.
Warnings
Do not use if you are pregnant. Avoid getting pregnant for at least 12 months after you stop using hyaluronidase and rituximab.
Rituximab may cause a serious brain infection that can lead to disability or death. Call your doctor right away if you have problems with speech, thought, vision, or muscle movement.
If you've ever had hepatitis B, using rituximab can cause this virus to become active or get worse.
Severe skin problems can also occur during treatment with rituximab. Call your doctor if you have painful skin or mouth sores, or a severe skin rash with blistering, peeling, or pus.
Some side effects may occur during the injection or within 24 hours afterward. Tell your caregiver right away if you feel itchy, dizzy, weak, light-headed, short of breath, chilled, feverish, or if you have chest pain, wheezing, a sudden cough, or pounding heartbeats or fluttering in your chest.
Before taking this medicine
Tell your doctor if you have ever had:
kidney disease;
lung disease;
a severe reaction to hyaluronidase or rituximab;
a weak immune system (caused by disease or by using certain medicines);
a severe infection such as herpes, shingles, cytomegalovirus, chickenpox, parvovirus, West Nile virus, or hepatitis B or C;
heart disease, angina (chest pain), or heart rhythm disorder; or
if you recently received any vaccine, or you are are scheduled to receive a vaccine.
Rituximab may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 12 ...
