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Hydrochlorothiazide and amiloride
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Hydrochlorothiazide and amiloride

Generic name: hydrochlorothiazide and amiloride [ hy-dro-klor-oh-THI-a-zide-and-a-MIL-o-ride ]
Brand name: Moduretic 5-50
Dosage form: oral tablet (5 mg-50 mg)
Drug class:Potassium sparing diuretics with thiazides

Medically reviewed by Drugs.com on Nov 22, 2021. Written by Cerner Multum.

What is hydrochlorothiazide and amiloride?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Amiloride is a potassium sparing-diuretic that also prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.

The combination of hydrochlorothiazide and amiloride is used to treat fluid retention (edema) and high blood pressure (hypertension).

Hydrochlorothiazide and amiloride may also be used for purposes not listed in this medication guide.

Warnings

You should not use hydrochlorothiazide and amiloride if you have kidney disease, urination problems, diabetes, or high levels of potassium in your blood.

Some medicines can cause unwanted or dangerous effects when used with hydrochlorothiazide and amiloride. Your doctor may need to change your treatment plan if you use potassium supplements or certain diuretics (spironolactone, triamterene).

If you have diabetes, do not use hydrochlorothiazide and amiloride together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna).

Before taking this medicine

You should not use this medication if you are allergic to hydrochlorothiazide or amiloride, or if you have:

  • kidney disease or are unable to urinate;

  • high potassium levels (hyperkalemia); or

  • if you are taking potassium supplements.

Some medicines can cause unwanted or dangerous effects when used with hydrochlorothiazide and amiloride. Your doctor may need to change your treatment plan if you use potassium supplements or certain diuretics (spironolactone, triamterene).

If you have diabetes, do not use hydrochlorothiazide and amiloride together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna).

To make sure hydrochlorothiazide and amiloride is safe for you, tell your doctor if you have: