Hydrochlorothiazide and lisinopril

Generic name: hydrochlorothiazide and lisinopril [ HYE-droe-KLOR-oh-THYE-a-zide-and-lye-SIN-oh-pril ]
Brand names: Zestoretic, Prinzide
Dosage form: oral tablet (12.5 mg-10 mg; 12.5 mg-20 mg; 25 mg-20 mg)
Drug class:ACE inhibitors with thiazides

Medically reviewed by Drugs.com on Feb 1, 2021. Written by Cerner Multum.

What is hydrochlorothiazide and lisinopril?

Hydrochlorothiazide is a thiazide diuretic (water pill). Lisinopril is in an ACE inhibitor (ACE stands for angiotensin converting enzyme).

Hydrochlorothiazide and lisinopril is a combination medicine used to treat hypertension (high blood pressure). Lowering blood pressure may lower your risk of a stroke or heart attack.

Hydrochlorothiazide and lisinopril may also be used for purposes not listed in this medication guide.

Warnings

Do not use if you are pregnant. If you become pregnant, stop taking hydrochlorothiazide and lisinopril and tell your doctor right away.

You should not use this medicine if you have ever had angioedema, if you are unable to urinate, or if you are allergic to sulfa drugs or to any ACE inhibitor. Do not take hydrochlorothiazide and lisinopril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).

If you have diabetes, do not use hydrochlorothiazide and lisinopril together with any medication that contains aliskiren (a blood pressure medicine).

Before taking this medici...