Class: Adrenals
ATC Class: H02AB09
VA Class: HS051
CAS Number: 50-23-7
Brands: A-hydroCort, Cortef, Solu-CORTEF
Introduction
Glucocorticoid secreted by the adrenal cortex; also exhibits mineralocorticoid activity.
Uses for Hydrocortisone (Systemic)
Treatment of a wide variety of diseases and conditions principally for glucocorticoid effects as an anti-inflammatory and immunosuppressant agent and for its effects on blood and lymphatic systems in the palliative treatment of various diseases.
When used for anti-inflammatory and immunosuppressant properties, synthetic glucocorticoids that have minimal mineralocorticoid activity are preferred.
Adrenocortical Insufficiency
Corticosteroids are administered in physiologic dosages to replace deficient endogenous hormones in patients with adrenocortical insufficiency.
Hydrocortisone or cortisone (in conjunction with liberal salt intake) is usually the corticosteroid of choice for replacement therapy in patients with adrenocortical insufficiency, because these drugs have both glucocorticoid and mineralocorticoid properties. Concomitant administration of a more potent mineralocorticoid (fludrocortisone) may be required in some patients.
In suspected or known adrenal insufficiency, parenteral therapy may be used preoperatively or during serious trauma, illness, or shock unresponsive to conventional therapy.
In shock, IV therapy in conjunction with other therapy for shock is essential; hydrocortisone is preferred.
Adrenogenital Syndrome
Lifelong glucocorticoid treatment of congenital adrenogenital syndrome.
In salt-losing forms, cortisone or hydrocortisone is preferred in conjunction with liberal salt intake; an additional mineralocorticoid may be necessary in conjunction through at least 5–7 years of age.
A glucocorticoid, usually alone, for long-term therapy after early childhood.
In hypertensive forms, a “short-acting” g...
