Hydrocortisone Butyrate Solution

Dosage form: topical solution
Drug class:Topical steroids

Medically reviewed by Drugs.com. Last updated on Apr 21, 2022.

Hydrocortisone Butyrate Solution Description

Hydrocortisone Butyrate Solution, 0.1% contains the topical corticosteroid, hydrocortisone butyrate, a nonfluorinated hydrocortisone ester. It has the chemical name: 11β,17,21-Trihydroxypregn-4-ene-3,20-dione 17-butyrate; the molecular formula: C25H36O6; the molecular weight: 432.54; and the CAS registry number: 13609-67-1.

Its structural formula is:

Each mL of Hydrocortisone Butyrate Solution contains 1 mg of hydrocortisone butyrate in a vehicle consisting of anhydrous citric acid, glycerin, isopropyl alcohol (50% v/v), povidone, purified water, and sodium citrate.

CLINICAL PHARMACOLOGY

Topical corticosteroids share anti-inflammatory, anti-pruritic, and vasoconstrictive actions. The mechanism of anti-inflammatory activity of topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists be...