Hydrocortisone Rectal Suspension

Dosage form: rectal suspension
Drug class:Glucocorticoids

Medically reviewed by Drugs.com. Last updated on Nov 1, 2021.

Hydrocortisone Rectal Suspension Description

Hydrocortisone is a white to practically white, odorless, crystalline powder, very slightly soluble in water. It has the chemical name Pregn-4-ene-3,20-dione,11,17,21-tri-hydroxy,(11β)-and the following structural formula:

C 21H 30O 5 M.W. 362.47

Hydrocortisone Rectal Suspension, USP is a convenient disposable single-dose hydrocortisone enema designed for ease of self-administration.

Each disposable unit (60 mL) contains: Hydrocortisone, 100 mg in an aqueous solution containing carbomer 934P, polysorbate 80, purified water, sodium hydroxide and methylparaben, 0.18% as a preservative.

Hydrocortisone Rectal Suspension - Clinical Pharmacology

Hydrocortisone is a naturally occurring glucocorticoid (adrenal corticosteroid), similar to its acetate and sodium hemisuccinate derivatives, is partially absorbed following rectal administration. Absorption studies in ulcerative colitis patients have shown up to 50% absorption of hydrocortisone a...