Hydrogen Peroxide 40%

Class: Skin and Mucous Membrane Agents, Miscellaneous
Chemical Name: hydrogen peroxide
Molecular Formula: H₂O₂
CAS Number: 218625-72-0
Brands: Eskata

Medically reviewed by Drugs.com on Dec 29, 2021. Written by ASHP.

Introduction

Hydrogen peroxide 40% is a skin agent.

Uses for Hydrogen Peroxide 40%

Hydrogen peroxide 40% has the following uses:

Hydrogen peroxide 40% is indicated for the treatment of seborrheic keratoses that are raised.

Hydrogen Peroxide 40% Dosage and Administration

General

Hydrogen peroxide 40% is available in the following dosage form(s) and strength(s):

Topical solution: 40% (w/w) hydrogen peroxide.

Dosage

It isessentialthat the manufacturer's labeling be consulted for more detailed information on dosage and administration of this drug. Dosage summary:

Adults

• To be administered by a healthcare provider.

• For topical use only. Not for oral, ophthalmic, or intravaginal use.

• Do not apply hydrogen peroxide 40% topical solution to open or infected seborrheic keratoses.

• Prior to application, clean targeted lesion(s) using an alcohol wipe. Apply hydrogen peroxide 40% topical solution 4 times, approximately 1 minute apart, to the targeted lesion(s) during a single in-office treatment session. Any excess solution on the surrounding skin should be removed using a clean absorbent wipe; do not use paper towels or tissue to remove excess solution.

• Another treatment may be administered if the treated lesions have not completely cleared by approximately 3 weeks after treatment.

Cautions for Hydrogen Peroxide 40%

Contraindications

None.

Warnings/Precautions

Eye Disorders

Do not apply to the eyes or mucous membranes. Avoid treating seborrheic keratoses within the orbital rim. Direct contact with the eye can cause corneal injury (erosion, ulceration, perforation, and scarring), chemical conjunctivitis, eyelid edema, severe eye pain, or permanent eye injury, including blindness.

If accidental exposure occurs, flush with water for 15 to 30 minutes and initiate monitoring and further evaluation as appropriate.

Local Skin Reactions

Skin reactions occurred in the treatment area after application of hydrogen peroxide 40%. Severe local skin reactions included erosion, ulceration, vesiculation and scarring. Do not initiate a second treatment course with hydrogen peroxide 40% until the skin has recovered from any reaction caused by the previous treatment.

Specific Populations

Pregnancy

Hydrogen peroxide is not absorbed systemically following topical administration, and maternal use is not expected to result in fetal exposure to the drug.

Lactation

Hydrogen peroxide is not absorbed systemically by the mother following topical administration, and breastfeeding is not expected to result in exposure of the child to hydrogen peroxide.

Pediatric Use

Seborrheic keratosis is not seen in the pediatric population.