IC-Green

Generic name:indocyanine green
Dosage form: injection, powder, lyophilized, for solution
Drug classes:Miscellaneous diagnostic dyes, Ophthalmic diagnostic agents

Medically reviewed by Drugs.com. Last updated on Jan 1, 2022.

Indications and Usage for IC-Green

IC-Green® is indicated:

For Determining Cardiac Output, Hepatic Function and Liver Blood Flow

For Ophthalmic Angiography

IC-Green Dosage and Administration

Indicator-Dilution Studies

In the performance of dye dilution curves, a known amount of dye is injected as a single bolus as rapidly as possible via a cardiac catheter into selected sites in the vascular system. A recording instrument (oximeter or densitometer) is attached to a needle or catheter for sampling of the dye-blood mixture from a systemic arterial sampling site.

Under sterile conditions, the IC-Green® powder should be dissolved with the Sterile Water for Injection, USP provided for this product, and the solution used within 6 hours after it is prepared. If a precipitate is present, discard the solution.

The usual doses of IC-Green® for dilution curves are as follows:

Adults - 5.0 mg

Children - 2.5 mg

Infants - 1.25 mg

These doses of the dye are usually injected in 1 mL volume. An average of five dilution curves are recommended in the performance of a diagnostic cardiac catheterization. The total dose of dye injected should be kept below 2 mg/kg.

While sterile water for injection may be used to rinse the syringe, isotonic saline should be used to flush the residual dye from the cardiac catheter into the circulation so as to avoid hemolysis. With the exception of the rinsing of the dye injection syringe, saline should be used in all other parts of the catheterization procedure.

Calibrating Dye Curves: To quantitate the dilution curves, standard dilutions of IC-Green® in whole blood are made as follows. It is strongly recommended that the same dye that was used for the injections be used in the prepar...