Generic name:ponatinib [ poe-NA-ti-nib ]
Drug classes:BCR-ABL tyrosine kinase inhibitors, Multikinase inhibitors, VEGF/VEGFR inhibitors
What is Iclusig?
Iclusig is a cancer medicine that interferes with the growth of some cancer cells.
Iclusig is used to treat adults with chronic phase chronic myeloid leukemia (CML) who did not tolerate or no longer benefit from treatment with at least 2 prior kinase inhibitor medicines.
Iclusig is used to treat adults with accelerated phase or blast phase CML, or Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) who cannot receive any other kinase inhibitor medicines.
Iclusig is also used to treat adults with a specific type of abnormal gene (T315I-positive) chronic phase, accelerated phase, or blast phase CML, or T315I-positive Ph+ ALL.
Iclusig is not for use to treat people with newly diagnosed chronic phase CML.
It is not known if Iclusig is safe and effective in children.
Warnings
Iclusig may cause heart or blood vessel problems that could lead to heart attack, stroke, or death.
Call your doctor or get emergency medical help if you have: chest pain spreading to your jaw or shoulder, shortness of breath, dizziness, severe stomach pain, swelling in your legs, sudden numbness or weakness, headache, or problems with vision or speech.
Iclusig may also harm your liver. Call your doctor right away if you have upper stomach pain with loss of appetite, dark urine, bruising, or yellowing of your skin or eyes.
