Idelalisib

Generic name: idelalisib [ eye-DEL-a-LIS-ib ]
Brand name: Zydelig
Dosage form: oral tablet (100 mg; 150 mg)
Drug class:PI3K inhibitors

Medically reviewed by Drugs.com on Nov 9, 2020. Written by Cerner Multum.

What is idelalisib?

Idelalisib is used together with rituximab to treat chronic lymphocytic leukemia, and certain types of lymphoma.

Idelalisib is sometimes given after at least two other cancer treatments did not work or have stopped working.

Idelalisib was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis to treat lymphoma. In clinical studies, some people responded to idelalisib, but further studies are needed.

Idelalisib may also be used for purposes not listed in this medication guide.

Warnings

Idelalisib can cause serious harm to your liver, lungs, or intestines. Some of these conditions may lead to fatal complications. Call your doctor right away if you have: upper stomach pain, easy bruising or bleeding, dark urine, yellowing of your skin or eyes, cough, wheezing, shortness of breath, fever, chills, worsening stomach pain, or vomiting.

You may have severe or life-threatening diarrhea while taking idelalisib. Tell your doctor at once if your daily bowel movements increase by 6 or more.

Before taking this medicine

You may not be able to use idelalisib if you have ever had a serious skin reaction to any medicine.

Tell your doctor if you have ever had:

• liver disease;

• lung disease; or

• a perforation (a hole or tear) in your intestines.

Idelalisib can harm an unborn baby if the mother or the father is using idelalisib.

• If you are a woman, do not use idelalisib if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 1 month after your last dose.

• If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.

• Tell your doctor right away if a pregnancy occurs while either the mother or the father is using idelalisib.

Do not breastfeed while using this medicine, and for at least 1 month after your last dose.

Idelalisib is not approved for use by anyone younger than 18 years old.

How should I take idelalisib?

Follow all directions on your prescription label and read al...