Ifosfamide

Generic name: ifosfamide [ eye-FOS-fah-mide ]
Brand name: Ifex
Dosage forms: intravenous powder for injection (1 g; 3 g); intravenous solution (50 mg/mL)
Drug class:Alkylating agents

Medically reviewed by Drugs.com on May 4, 2022. Written by Cerner Multum.

What is ifosfamide?

Ifosfamide is used with other medicines to treat testicular cancer in men.

Ifosfamide is usually given after other treatments have failed.

Ifosfamide may also be used for purposes not listed in this medication guide.

Warnings

You should not receive ifosfamide if you have a medical condition that causes urination problems (such as an enlarged prostate).

Ifosfamide affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, cough, mouth sores, or unusual bleeding or bruising.

Ifosfamide can affect your kidneys or nervous system. Call your doctor at once if you have urination problems, blood in your urine, problems with your hearing or vision, unusual thoughts or behavior, hallucinations, or a seizure.

Before taking this medicine

You should not be treated with ifosfamide if you are allergic to it, or if you have a medical condition that causes urination problems (such as an enlarged prostate).

Tell your doctor if you have ever had:

• kidney disease;

• heart disease;

• a bladder infection;

• treatment with busulfan; or

• radiation treatment of your bladder.

Using ifosfamide may increase your risk of developing other cancers, such as leukemia. Ask your doctor about this risk.

Ifosfamide can cause birth defects if a woman is exposed to it during pregnancy.

Use effective birth control to prevent pregnancy, whether you are a man or a woman. Ifosfamide use by either parent may cause birth defects. Keep using birth control for at least 6 months after treatment.

This medication may affect fertility (your ability to have children), whether you are a man or a woman. Some women using ifosfamide have stopped having periods, or started having symptoms of early menopause.

A woman receiving ifosfamide should not breast-feed.

How is ifosfamide given?

Your doctor will perform blood and urine tests to make sure you do not have conditions that would prevent you from safely using ifosfamide.

Ifosfamide is given as an infusion into a vein. A healthcare provider will give you this injection.

If this medicine accidentally gets on your skin, wash it thoroughly with soap and warm water.

Ifosfamide is given i...