Imipenem, cilastatin, and relebactam (Intravenous)

Medically reviewed by Drugs.com. Last updated on Mar 24, 2022.

Commonly used brand name(s)

In the U.S.

• Recarbrio

Available Dosage Forms:

• Powder for Solution

Therapeutic Class: Antibiotic

Pharmacologic Class: Beta-Lactam

Chemical Class: Carbapenem

Uses for imipenem, cilastatin, and relebactam

Imipenem, cilastatin, and relebactam combination injection is used to treat complicated bacterial infections in many different parts of the body (eg, kidneys, stomach). Imipenem, cilastatin, and relebactam is also used to treat hospital-acquired and ventilator-associated bacterial pneumonia.

Imipenem, cilastatin, and relebactam is an antibiotic that works by killing bacteria or preventing their growth. It will not work for colds, flu, or other virus infections.

Imipenem, cilastatin, and relebactam is to be given only by or under the direct supervision of your doctor.

Before using imipenem, cilastatin, and relebactam

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For imipenem, cilastatin, and relebactam, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to imipenem, cilastatin, and relebactam or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of imipenem, cilastatin, and relebactam combination injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of imipenem, cilastatin, and relebactam combination injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving imipenem, cilastatin, and relebactam.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving imipenem, cilastatin, and relebactam, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using imipenem, cilastatin, and relebactam with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Bup...