Imiquimod

Class: Skin and Mucous Membrane Agents, Miscellaneous
VA Class: IM900
Chemical Name: 1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
Molecular Formula: C₁₄H₁₆N₄
CAS Number: 99011-02-6
Brands: Aldara

Medically reviewed by Drugs.com on Jul 22, 2021. Written by ASHP.

Introduction

Immune response modifier; imidazoquinoline amine.

Uses for Imiquimod

Actinic Keratosis

Topical treatment of clinically typical, nonhyperkeratotic, nonhypertrophic actinic keratosis on the face or scalp in immunocompetent adults.

Basal Cell Carcinoma

Topical treatment of biopsy-confirmed, primary superficial basal cell carcinoma in immunocompetent adults. Safety and efficacy not established for other types of basal cell carcinoma, including nodular and morpheaform (fibrosing or sclerosing) types.

Use only when superficial basal cell carcinoma tumor diameter is ≤2 cm and is located on the trunk (excluding anogenital skin), neck, or extremities (excluding hands and feet).

Use only when surgical methods are medically less appropriate and patient follow-up can be reasonably assured.

Human Papillomavirus (HPV) Infections

Treatment of external genital and perianal exophytic warts (condylomata acuminata) caused by HPV in adults and adolescents ≥12 years of age.

CDC and others recommend that external HPV warts be treated with a self-administered topical therapy (imiquimod, podofilox), a topical therapy administered by a health-care provider (podophyllum resin, trichloroacetic acid [TCA], bichloroacetic acid [BCA]), or a surgical technique (cryotherapy, electrosurgery, surgical excision). Alternative therapies include intralesional interferon alfa or laser surgery.

A preferred treatment regimen for external genital HPV warts in HIV-infected† adults and adolescents; data are limited regarding the response rate in HIV-infected patients compared with those without HIV infe...