Inotersen (Subcutaneous)
Medically reviewed by Drugs.com. Last updated on Apr 7, 2022.
ThrombocytopeniaInotersen causes reductions in platelet count that may result in sudden and unpredictable thrombocytopenia, which can be life-threatening.Testing prior to treatment and monitoring during treatment is required.GlomerulonephritisInotersen can cause glomerulonephritis that may require immunosuppressive treatment and may result in dialysis-dependent renal failure.Testing Prior to treatment and monitoring during treatment is required.TEGSEDI is only available through a restricted distribution program call the TEGSEDI REMS Program .
Commonly used brand name(s)
In the U.S.
- Tegsedi
Available Dosage Forms:
- Solution
Therapeutic Class: Endocrine-Metabolic Agent
Pharmacologic Class: Antisense Oligonucleotide
Uses for inotersen
Inotersen injection is used to treat polyneuropathy (nerve disease) of hereditary transthyretin-mediated amyloidosis.
Inotersen is available only under a restricted distribution program called Tegsedi™ REMS (Risk Evaluation and Mitigation Strategy) Program.
Before using inotersen
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For inotersen, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to inotersen or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of inotersen injection in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of inotersen injection in the elderly. However, elderly patients are more likely to have serious unwanted effects (including heart failure, chills, myalgia, or pain in the arms or legs), which may require caution in patients receiving inotersen.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking inotersen, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using inotersen with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often ..
