Inrebic
Generic name:fedratinib [ fed-RA-ti-nib ]
Drug class:Multikinase inhibitors
What is Inrebic?
Inrebic is a prescription medicine used to treat myelofibrosis in adults.
Myelofibrosis is a rare type of bone marrow cancer that affects your body's ability to produce blood cells.
It is not known if Inrebic is safe and effective in children.
Warnings
Some people using Inrebic have developed vitamin B1 deficiency that resulted in serious and sometimes fatal brain damage. Your vitamin B1 levels will need to be checked before and during treatment, and you may need to take a vitamin B1 supplement.
Get emergency medical help if you have symptoms such as drowsiness, confusion, memory problems, vision problems, unusual eye movements, or problems with coordination and muscle movement.
Call your doctor if you are sick with vomiting or diarrhea even while taking medications to prevent these side effects.
Before taking this medicine
To make sure Inrebic is safe for you, tell your doctor if you have ever had:
low levels of platelets or red blood cells;
kidney disease; or
if you have been taking ruxolitinib (Jakafi).
It is not known whether fedratinib will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
You should not breastfeed while using Inrebic, and for at least 1 month after your last dose.
How should I take Inrebic?
Take Inrebic exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
You may take Inrebic with or without food. Take with a high-fat meal if Inrebic upsets your stomach.
Your vitamin B1 (thiamine) levels will need to be checked before and during treatment with Inrebic. You may need to take a vitamin B1 supplement.
You may be given other medications to help prevent nausea, vomiting, and diarrhea. Keep using these medicines for as long as your doctor has prescribed.
Some people using Inrebic have developed vitamin B1 deficiency that resulted in serious and sometimes fatal brain damage. Your vitamin B1 levels will need to be checked before and during treatment with Inrebic. You may need to take a vitamin B1 supplement.
Call your doctor if you are sick with vomiting or diarrhea even while taking medications to prevent these side effects. You can easily become malnourished from vomiting and diarrhea. This can lead to low vitamin B1 levels.
Fedratinib ...
