Insulin lispro and insulin lispro protamine

Generic name: insulin lispro and insulin lispro protamine [ IN-soo-lin-LISS-pro-and-IN-soo-lin-LISS-pro-PRO-ta-meen ]
Brand names: HumaLOG Mix 50/50, HumaLOG Mix 50/50 KwikPen, HumaLOG Mix 75/25, HumaLOG Mix 75/25 KwikPen, HumaLOG Mix 75/25 Pen, HumaLOG Mix 50/50 Pen, Insulin Lispro Protamine-Insulin Lispro Mix75/25 KwikPen
Dosage form: subcutaneous suspension (25 units-75 units/mL; 50 units-50 units/mL)
Drug class:Insulin

Medically reviewed by Drugs.com on Mar 28, 2022. Written by Cerner Multum.

What is insulin lispro and insulin lispro protamine?

Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Insulin lispro is a fast-acting insulin. Insulin lispro protamine is an intermediate-acting insulin. This combination insulin starts to work within 10 to 20 minutes after injection, peaks in 2 hours, and keeps working for up to 24 hours.

Insulin lispro and insulin lispro protamine is a combination medicine used to improve blood sugar control in adults with diabetes mellitus. insulin lispro and insulin lispro protamine may be used for type 1 or type 2 diabetes.

Insulin lispro and insulin lispro protamine may also be used for purposes not listed in this medication guide.

Warnings

Never share an injection pen, cartridge, or syringe with another person, even if the needle has been changed.

Before taking this medicine

You should not use this medicine if you are allergic to insulin lispro, or if you are having an episode of hypoglycemia (low blood sugar).

Insulin lispro and insulin lispro protamine is not approved for use by anyone younger than 18 years old.

Tell your doctor if you have ever had:

• liver or kidney disease; or

• low levels of potassium in your blood (hypokalemia).

Tell your doctor if you also take pioglitazone or rosiglitazone (sometimes contained in combinations with glimepiride or metformin). Taking certain oral diabetes medicines while you are using insulin may increase...