Invokamet XR

Generic name:canagliflozin and metformin [ KAN-a-gli-FLOE-zin-and-met-FOR-min ]
Brand names: Invokamet, Invokamet XR
Drug class:Antidiabetic combinations

Medically reviewed by Drugs.com on Sep 8, 2020. Written by Cerner Multum.

What is Invokamet XR?

Invokamet XR is a combination medicine used with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Invokamet XR is also used to lower the risk of death from heart attack, stroke, or heart failure in adults with type 2 diabetes who also have heart disease.

Invokamet XR is also used to reduce the risk of end-stage kidney disease and hospitalization or death from heart problems in adults who also have kidney problems caused by type 2 diabetes.

Invokamet XR is not for treating type 1 diabetes.

Invokamet XR may also be used for purposes not listed in this medication guide.

Warnings

You should not use this medicine if you have severe kidney disease or diabetic ketoacidosis.

Canagliflozin can cause serious infections in the penis or vagina. Get medical help right away if you have burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, or if you don't feel well.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.

Before taking this medicine

You should not use Invokamet XR if you are allergic to canagliflozin or metformin, or if you have:

• severe kidney disease; or

• ketoacidosis (call your doctor for treatment).

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Invokamet XR.

Canagliflozin may increase your risk of lower leg amputation, especially if you have had a prior amputation, a foot ulcer, heart disease, circulation problems, or nerve damage.

Tell your doctor if you have ever had:

• heart problems;

• a diabetic foot ulcer or amputation;

• circulation problems or nerve problems in your...