Iobenguane i 131 (Intravenous)

Commonly used brand name(s)

In the U.S.

• Azedra

Available Dosage Forms:

• Solution

Therapeutic Class: Diagnostic Agent, Radiopharmaceutical Imaging

Uses for iobenguane i 131

Iobenguane I 131 injection is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to find and treat certain diseases or to study the function of the body's organs.

Iobenguane I 131 injection is used to treat iobenguane scan positive, advanced or metastatic (cancer that has spread) pheochromocytoma (cancer of the adrenal glands) or paraganglioma in patients who cannot be treated by surgery and who require systemic cancer treatment.

When very small doses of radioiodinated iobenguane are given, the radioactivity taken up by the adrenal glands helps find the tumors. An image of the gland on film or on a computer screen can be provided to help with the diagnosis.

Iobenguane i 131 is to be given only by or under the direct supervision of a doctor with specialized training in nuclear medicine or radiation oncology.

Before using iobenguane i 131

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For iobenguane i 131, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to iobenguane i 131 or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of iobenguane I 131 injection in children 12 years of age and older. Safety and efficacy have been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of iobenguane I 131 injection in the elderly.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving iobenguane i 131, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using iobenguane i 131 with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Amineptine
• Amitriptyline
• Amitriptylinoxide
• Amoxapine
• Amphetamine
• Apraclonidine
• Armodafinil
• Benzphetamine
• Brimonidine
• Bupropion
• Caffeine
• Carteolol
• Carvedilol
• Citalopram
• Clomipramine
...