Iobenguane sulfate I 131
Dosage form: injection
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Iobenguane sulfate I 131 Description
Iobenguane sulfate I 131 Injection is a sterile, pyrogen free radiopharmaceutical for intravenous injection. Each milliliter contains 0.69 mg of iobenguane sulfate, 85.1 MBq (2.30 mCi) of I 131 (as Iobenguane sulfate I 131 at calibration), 0.36 mg of sodium acetate, 0.27 mg of acetic acid, 4.2 mg of sodium chloride, 0.56 mg of methyl paraben, 0.056 mg of propylparaben and 0.01 mL of benzyl alcohol. Iobenguane sulfate I 131 is also known as I 131-meta-iodobenzylguanidine sulfate (I 131 MIBG) and has the following structural formula:
Iobenguane sulfate I 131
(I 131-meta-iodobenzylguanidine sulfate)
Physical Characteristics
Iobenguane sulfate I 131 is a radioiodinated arylalkylguanidine. It is similar in structure to the anti-hypertensive drug guanethidine and to the neurotransmitter norepinephrine.
Iodine 131 decays by beta and gamma emission and has a physical half-life of 8.04 days. The principal beta particles and those photons that are useful for detection and imaging are listed in Table 1.
| Radiation | Mean Percentage Disintegration | Energy (kev) |
| Beta-1 | 2.1 | 69.4 avg |
| Beta-3 | 7.4 | 96.6 avg |
| Beta-4 | 89.3 |
MEDICAL DEPARTMENTS
Cardiology
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Diabetes Care
Pre-natal Care
Ultrasound Echocardiogram
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