Iodopen Sodium Iodide Injection

Dosage form: injection, solution
Drug class:Minerals and electrolytes

Medically reviewed by Drugs.com. Last updated on Dec 22, 2021.

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Trace Element Additive

FOR IV USE ONLY AFTER DILUTION

Iodopen Sodium Iodide Injection Description

Iodopen (Sodium Iodide Injection) is a sterile, nonpyrogenic solution for use as an additive to solutions for total parenteral nutrition (TPN).

Each mL contains:

Sodium Iodide

(equivalent to 100 mcg iodide) .....118 mcg

Water for Injection, USP .....q.s.

pH adjusted with sodium hydroxide or hydrochloric acid.

Iodopen Sodium Iodide Injection - Clinical Pharmacology

Iodine is an integral part of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). The hormones regulate basal metabolism. The thyroid function is modulated by hypothalmicpituitary axis through thyroid-releasing hormone and thyroid-stimulating hormone by negative feed back of thyroxine levels in plasma. The essentiality of iodine in humans and animals is well established. Persistent iodine deficiency results in histological changes in thyroid gland and impaired thyroid function, which may culminate in goiter. Iodine deficiency in early stage in life has been reported to produce cretinism. Published reports on pharmacokinetics of iodine in humans and animals show that absorption of iodine from the gastrointestinal tract is rapid and complete.

Skin and lungs can also absorb iodine. Iodine is utilized as iodide or iodated organic complexes. On administration iodide equilibrates in extracellular fluids and although all body cells contain iodide, it is specifically concentrated by thyroid gland, which, in humans, is estimated to contain 7 to 8 mg total iodine.

Other important organs to take up iodide are salivary glands and gastric mucosa, and to a lesser extent, choroid plexus, skin, hair, mammary glands and placenta. Iodine in saliva and gastric mucosal secretions is reabsorbed and recycled. The circulating iodine is hor...