Iodoquinol (Topical)
Class: Local Anti-infectives, Miscellaneous
ATC Class: G01AC01
VA Class: DE400
CAS Number: 83-73-8
Brands: Alcortin, Dermazene, Vytone
Introduction
Anti-infective agent; halogenated 8-hydroxyquinoline.
Uses for Iodoquinol (Topical)
Dermatoses
Principally used in combination with hydrocortisone for the topical treatment of subacute and chronic dermatoses.
National Research Council and FDA state that iodoquinol/hydrocortisone combinations are “possibly” effective for topical treatment of eczema (e.g., impetiginized eczema, nummular eczema, infantile eczema, nuchal eczema) and dermatitis (e.g., contact, atopic, endogenous chronic infectious, stasis, localized or disseminated neurodermatitis). Also may be effective for treatment of bacterial dermatoses, mycotic dermatoses [e.g., tinea (capitis, cruris, corporis, pedis), pyoderma, chronic eczematoid otitis externa, acne urticata, lichen simplex chronicus, anogenital pruritus (vulvae, scroti, ani), folliculitis, moniliasis, and intertrigo. .
Has been used topically in a suitable dermatologic vehicle alone or in combination with coal tar† in the treatment of bacterial and fungal infections of the skin.
Has been used in the treatment of diaper rash (diaper dermatitis); however, use in children currently is not recommended. (See Pediatric Use under Cautions.)
Seborrheic Dermatitis
Has been used as a shampoo (no longer commercially available in the US) for control of seborrheic dermatitis of the scalp†; however, relapse usually occurs when the drug is discontinued.
Iodoquinol (Topical) Dosage and Administration
Administration
Topical Administration
Apply topically to the skin as a cream or gel.
For external use only; avoid contact with the eyes.
Do not use over large areas of skin for long periods.
Dosage
Adults
Dermatoses
Topical
Apply combination cream or gel (iodoquinol 1% and hydrocortisone 1–2%) to affected area(s) 3 or 4 times daily as directed.
Prescribing Limits
Adults
Dermatoses
Topical
Not recommended for prolonged use. (See Superinfection under Warnings.)
Special Populations
Geriatric Patients
Generally, select dosage with caution, usually initiating at the lower end of the usual range, because of age related decreases in hepatic, renal, and/or cardiac function and concomitant disease or drug therapy.
