Ipratropium (EENT)

Class: EENT Drugs, Miscellaneous
VA Class: NT900
Chemical Name: (endo,syn-±-3-(3-Hydroxy-1-oxo-2-pheny lpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane bromide monohydrate
Molecular Formula: C₂₀H₃₀BrNO₃•H₂O
CAS Number: 66985-17- 9
Brands: Atrovent Nasal Spray

Medically reviewed by Drugs.com on Jul 22, 2021. Written by ASHP.

Introduction

Synthetic quaternary ammonium antimuscarinic.

Uses for Ipratropium (EENT)

Common Cold

Symptomatic relief of rhinorrhea associated with the common cold in adults and children ≥5 years of age. Does not relieve nasal congestion or sneezing.

Seasonal Allergic Rhinitis

Symptomatic relief of rhinorrhea associated with seasonal allergic rhinitis in adults and children ≥5 years of age. Does not relieve nasal congestion, sneezing, or itching eyes.

Perennial Rhinitis

Symptomatic relief of rhinorrhea associated with allergic and nonallergic perennial rhinitis in adults and children ≥6 years of age. Does not relieve nasal congestion, sneezing, or postnasal drip.

Ipratropium (EENT) Dosage and Administration

Administration

Intranasal Administration

Administer in each nostril 2–4 times daily using spray pump supplied by the manufacturer.

Prime pump before first dose with 7 sprays; if used regularly, no further priming required. If not used for >24 hours, reprime with 2 sprays; if not used for >7 days, reprime with 7 sprays.

Dosage

Intranasal spray pump delivers 0.07 mL of solution per actuation.

Ipratropium bromide 0.03% nasal spray delivers 21 mcg of ipratropium bromide per spray and about 345 sprays per bottle.

Ipratropium bromide 0.06% nasal spray delivers 42 mcg of ipratropium bromide per spray and about 165 sprays per bottle.

Pediatric Patients

Common Cold

Intranasal

Children 5–11 years of age: 84 mcg (2 sprays of the 0.06% solution) in each nostril 3 times daily.

Child...