Isturisa

Generic name:osilodrostat [ O-sil-OH-droe-stat ]
Drug class:Adrenal corticosteroid inhibitors

Medically reviewed by Judith Stewart, BPharm. Last updated on May 30, 2022.

What is Isturisa?

Isturisa is a cortisol synthesis inhibitor.

Isturisa is used in adults to treat Cushing's disease that cannot be treated with pituitary surgery.

Isturisa is also used in patients who have had pituitary surgery, but the surgery did not cure their Cushing’s disease.

Warnings

Isturisa can cause serious side effects, such as heartbeat problems or decreased adrenal gland hormones. Call your doctor at once if you have irregular heartbeats, stomach pain, vomiting, loss of appetite, tiredness, or feeling light-headed.

Tell your healthcare provider if you take medicines used to treat certain heart problems.

Before taking this medicine

To make sure Isturisa is safe for you, tell your doctor if you have ever had:

• a heart rhythm disorder;

• long QT syndrome (in you or a family member);

• congestive heart failure;

• high blood pressure;

• an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);

• fluid retention; or

• liver disease.

Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether osilodrostat will harm an unborn baby. However, having Cushing's disease during pregnancy may cause complications such as diabetes or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby)....