Ivacaftor
Generic name: ivacaftor [ EYE-va-KAF-tor ]
Brand name: Kalydeco
Dosage forms: oral granule for reconstitution (25 mg; 50 mg; 75 mg); oral tablet (150 mg)
Drug class:CFTR potentiators
What is ivacaftor?
Ivacaftor is used to treat cystic fibrosis in adults and children who are at least 4 months old and weigh at least 11 pounds (5 kilograms).
Ivacaftor is for use only in patients with a specific gene mutation related to cystic fibrosis. Before you take ivacaftor, you may need a medical test to make sure you have this gene mutation.
Ivacaftor may also be used for purposes not listed in this medication guide.
Warnings
Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.
Before taking this medicine
Some medicines can cause unwanted or dangerous effects when used with ivacaftor. Your doctor may change your treatment plan if you also use:
rifabutin or rifampin;
St. John's wort; or
seizure medicine such as carbamazepine, phenobarbital, or phenytoin.
Tell your doctor if you have ever had:
liver disease; or
kidney disease.
It is not known whether ivacaftor will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
Ivacaftor should not be given to a child younger than 4 months old, or to a child with liver problems who is 4 months to less than 6 months old.
How should I take ivacaftor?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Take ivacaftor with food that contains fat, such as butter, peanut butter, eggs, cheese, whole milk, yogurt, or cheese pizza. Follow your doctor's instructions very carefully.
To use ivacaftor oral granules: Mix the granules with 1 teaspoon of liquid or soft food such as water, juice, milk, pudding, yogurt, or applesauce. Mix only 1 dose at a time, and use the mixture within 1 hour after mixing. Feed the child a high-fat food just before or just after giving the granule mixture.
Take your doses at regular intervals, 12 hours apart.
Ivacaftor doses are based on age and weight in children. Children from 4 months to 5 years old should take oral granules. Children 6 and older should take tablets.
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