Juvisync

Generic name:simvastatin and sitagliptin [ SIM-va-stat-in-and-SIT-a-GLIP-tin ]
Drug classes:Antidiabetic combinations, Antihyperlipidemic combinations

Medically reviewed by Drugs.com. Last updated on Jun 14, 2021.

What is Juvisync?

Juvisync contains a combination of simvastatin and sitagliptin. Simvastatin is an HMG CoA reductase inhibitor, or "statin." Simvastatin reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL).

Sitagliptin is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating.

Juvisync is used in people with type 2 diabetes who also have high cholesterol or triglycerides (types of fat) in the blood. This medication is not for treating type 1 diabetes.

Juvisync is also used to lower the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary heart disease, or other risk factors.

Juvisync may also be used for purposes not listed in this medication guide.

Warnings

Juvisync is a combination medicine for people with type 2 diabetes who also have high cholesterol.

You should not use Juvisync if you have liver disease or severe kidney disease. Do not use if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Do not use Juvisync if you are pregnant, and stop taking the medicine if you become pregnant.

Do not use this medicine if you are breast-feeding.

Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Also call your doctor if you have severe pain in your upper stomach spreading to your back.

There are many other drugs that should not be used together with Juvisync. Tell your doctor about all other medicines you use. Do not consume grapefruit products while taking this medicine.

Before taking this medicine

You should not use Juvisync if you are allergic to simvastatin or sitagliptin, or if you have:

• liver disease;

• severe kidney disease;

• if you are pregnant or breast-feeding; or

• if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

There are many other drugs that should not be used together with this medicine. Some medicines can cause unwanted or dangerous effects when used with Juvisync. Your doctor may need to change your treatment plan if you use any of the following drugs:

• cyclosporine;

• danazol;

• gemfibrozil;

• nefazodone;

• certain antibiotics--clarithromycin, erythromycin, or telithromycin;

• certain antifungal medications--itraconazole, ...