Generic name:levoleucovorin (intravenous route) [ lee-voe-loo-koe-VOE-rin ]
Drug class:Antidotes
Medically reviewed by Drugs.com. Last updated on Apr 24, 2022.
Commonly used brand name(s)
In the U.S.
- Fusilev
- Khapzory
Available Dosage Forms:
- Powder for Solution
- Solution
Therapeutic Class: Methotrexate Rescue
Uses for Khapzory
Levoleucovorin injection is used as a rescue treatment after high-dose methotrexate treatment in patients with osteosarcoma (bone cancer). It is also used to lessen the toxic effects of folic acid blocker overdose or methotrexate in patients who cannot eliminate this drug properly from their bodies. Levoleucovorin injection is also used together with fluorouracil to treat metastatic (cancer that has spread) colon or rectal cancer.
This medicine is to be given by or under the direct supervision of your doctor.
Before using Khapzory
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of levoleucovorin injection in children as rescue treatment after high-dose methotrexate treatment in osteosarcoma.
Appropriate studies have not been performed on the relationship of age to the effects of levoleucovorin injection in children to treat metastatic colorectal cancer. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific probl...
