Kimmtrak

Generic name:tebentafusp-tebn
Dosage form: injection
Drug class:Miscellaneous antineoplastics

Medically reviewed by Judith Stewart, BPharm. Last updated on Jan 31, 2022.

What is Kimmtrak?

Kimmtrak is a prescription medicine used to treat HLA-A*02:01-positive adults with uveal melanoma that cannot be removed by surgery or has spread.

Your healthcare provider will test you for a presence of HLA-A*02:01 gene to make sure Kimmtrak is right for you. It is not known if this medicine is safe and effective in children.

Important information

Kimmtrak can cause serious side effects that can be severe or, life threatening, and usually happens within the first three infusions. These side effects include:

• Cytokine Release Syndrome (CRS). Tell your healthcare provider right away if you get any of the following symptoms:
  • fever
  • tiredness or weakness
  • vomiting
  • chills
  • nausea
  • low blood pressure
  • dizziness and light headedness
  • headache
  • wheezing and trouble breathing
  • rash

Your healthcare provider will check for these problems during treatment. Your healthcare provider may temporarily stop or completely stop your treatment if you have severe side effects.

See Kimmtrak side effects for more information about side effects.

Before you receive Kimmtrak

Before you receive Kimmtrak, tell your healthcare provider about all of your medical conditions, including if you:

• are pregnant or plan to become pregnant. Kimmtrak may harm your unborn baby. Tell your healthcare provider if you become pregnant during treatment.

For females who are able to become pregnant:

• Your healthcare provider should do a pregnancy test before you start treatment.
• Use an effective form of birth control during treatment, and for at least 1 week after the last dose.
• are breastfeeding or plan to breastfeed. It is not known if Kimmtrak passes into your breast milk. Do not breastfeed during the treatment, and for at least 1 week after the last dose.

What other drugs will affect Kimmtrak?

Tell your healthcare provider about all medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How will I receive Kimmtrak?

• Kimmtrak will be given to you by intravenous (IV) infusion into your vein for 15 to 20 minutes.
• Kimmtrak is usually given every week.
• Your healthcare provider will decide how many treatments you need.
• Your healthcare provider will keep you under observation for at least 16 hours following the first three treatments and for at least 30 minutes after future treatments.
• Your healthcare provider may delay your treatment if you have certain side effects.
• Your healthcare provider may do blood tests regularly during treatment.

Dosing information

Usual Adult Dose for Uveal Melanoma

- 20 mcg intravenous..