Klotrix
Generic name:potassium chloride
Dosage form: tablets
Drug class:Minerals and electrolytes
Medically reviewed by Drugs.com. Last updated on Jun 21, 2021.
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The Klotrix brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
Klotrix Description
Klotrix® (potassium chloride) is a solid, oral dosage form of potassium chloride containing 750 mg of potassium chloride, USP (equivalent to 10 mEq of potassium) in a film-coated wax-matrix tablet. This formulation is intended to provide a controlled release of potassium from the matrix to minimize the likelihood of producing high, localized concentrations of potassium within the gastrointestinal tract.
Klotrix is an electrolyte replenisher. The chemical name is potassium chloride, and the structural formula is KCl. Potassium chloride, USP, occurs as a white, granular powder or as colorless crystals. It is odorless and has a saline taste. Its solutions are neutral to litmus. It is freely soluble in water and insoluble in alcohol.
This product contains the following inactive ingredients: ethylcellulose, FD&C Yellow No. 6 (aluminum lake), glycerin, hydroxypropyl methylcellulose 2910, magnesium stearate, povidone, colloidal silicon dioxide, stearic acid, and titanium dioxide.
Klotrix - Clinical Pharmacology
The potassium ion is the principal intracellular cation of most body tissues. Potassium ions participate in a number of essential physiological processes including the maintenance of intracellular tonicity, the transmission of nerve impulses, the contraction of cardiac, skeletal, and smooth muscle, and the maintenance of normal renal function.
The intracellular concentration of potassium is approximately 150 to 160 mEq per liter. The normal adult plasma concentration is 3.5 to 5 mEq per liter. An active ion transport system maintains this gradient across the plasma membrane.
Potassium is a normal dietary constituent and, under steady-state conditions, the amount of potassium absorbed from the gastrointestinal tract is equal to the amount excreted in the urine. The usual dietary intake of potassium is 50 to 100 mEq per day.
Potassium depletion will occur whenever the rate of potassium loss ...
