Kombiglyze XR

Generic name:metformin and saxagliptin [ met-FOR-min-and-SAX-a-GLIP-tin ]
Drug class:Antidiabetic combinations

Medically reviewed by Sanjai Sinha, MD. Last updated on Apr 21, 2022.

What is Kombiglyze XR?

Kombiglyze XR contains a combination of metformin and saxagliptin. Metformin and saxagliptin are oral diabetes medicines that help control blood sugar levels.

Metformin works by decreasing glucose (sugar) production in the liver and decreasing absorption of glucose by the intestines. Saxagliptin works by regulating the levels of insulin your body produces after eating.

Kombiglyze XR is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Kombiglyze XR is not for treating type 1 diabetes.

Warnings

You should not use Kombiglyze XR if you have severe kidney disease or diabetic ketoacidosis (call your doctor for treatment).

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.

Before taking this medicine

You should not use Kombiglyze XR if you are allergic to metformin or saxagliptin (Onglyza), or if you have severe kidney disease or diabetic ketoacidosis (call your doctor for treatment with insulin).

Tell your doctor if...