Generic name:pegloticase [ peg-LOE-ti-kase ]
Drug class:Antihyperuricemic agents
Medically reviewed by Drugs.com. Last updated on Aug 26, 2021.
What is Krystexxa?
Krystexxa is an enzyme that metabolizes uric acid into a harmless chemical that is eliminated from the body in urine.
Krystexxa injection is a prescription medicine used in adults to help reduce the signs and symptoms of gout that are not controlled by other treatments.
Krystexxa is usually given after other gout medications have been tried without successful treatment of symptoms.
Warnings
You should not receive Krystexxa if you are allergic to pegloticase, or if you have a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Some drugs can interact with Krystexxa and should not be used at the same time, especially allopurinol (Zyloprim), probenecid (Benemid), or febuxostat (Uloric).
Tell your caregivers right away if you feel itchy, light-headed, short of breath, or have chest discomfort or skin redness during the injection.
You may be given other medications to prevent certain side effects of Krystexxa. You may need to start taking these medications at least a week before you receive your injection. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Tell your caregiver right away if you feel itchy, nervous, light-headed, short of breath, or have a fast heartbeat, chest discomfort, or redness of your skin when the medicine is injected into your vein.
Before taking this medicine
You should not be treated with Krystexxa if you are allergic to pegloticase, or if you have a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Some medicines can cause unwanted or dangerous effects when used with Krystexxa. Your doctor may change your treatment plan if you also use:
