Kytril Injection

Generic name: granisetron hydrochloride
Dosage form: injection, solution
Drug class:5HT3 receptor antagonists

Medically reviewed by Drugs.com. Last updated on Mar 22, 2022.

Indications and Usage for Kytril Injection

Kytril Injection is a serotonin-3 (5-HT3) receptor antagonist indicated for:

• The prevention of nausea and/or vomiting associated with initial and repeat courses of emetogenic cancer therapy, including high-dose cisplatin.
• The prevention and treatment of postoperative nausea and vomiting in adults. As with other antiemetics, routine prophylaxis is not recommended in patients in whom there is little expectation that nausea and/or vomiting will occur postoperatively. In patients where nausea and/or vomiting must be avoided during the postoperative period, Kytril Injection is recommended even where the incidence of postoperative nausea and/or vomiting is low.

Kytril Injection Dosage and Administration

Prevention of Chemotherapy-Induced Nausea and Vomiting

Adult Patients

The recommended dosage for Kytril Injection is 10 mcg/kg administered intravenously within 30 minutes before initiation of chemotherapy, and only on the day(s) chemotherapy is given.

Infusion Preparation

Kytril Injection may be administered intravenously either undiluted over 30 seconds, or diluted with 0.9% Sodium Chloride or 5% Dextrose and infused over 5 minutes.

Stability

Intravenous infusion of Kytril Injection should be prepared at the time of administration. However, Kytril Injection has been shown to be stable for at least 24 hours when diluted in 0.9% Sodium Chloride or 5% Dextrose and stored at room temperature under normal lighting conditions.

As a general precaution, Kytril Injection should not be mixed in solution with other drugs. Parenteral drug products should be inspected visually for particulate matter and discoloration before administration whenever solution and container permit.

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