Laronidase
Generic name: laronidase [ lar-ON-i-dase ]
Brand name: Aldurazyme
Dosage form: intravenous solution (2.9 mg/5 mL)
Drug class:Lysosomal enzymes
What is laronidase?
Laronidase contains an enzyme that occurs naturally in the body in healthy people. Some people lack this enzyme because of a genetic disorder. Laronidase helps replace this missing enzyme in such people.
Laronidase is used to treat some of the symptoms of a genetic condition called mucopolysaccharidosis (MYOO-koe-pol-ee-SAK-a-rye-DOE-sis) or MPS I, also called Hurler syndrome, Hurler-Scheie syndrome, or Scheie syndrome.
MPS I is a metabolic disorder in which the body lacks the enzyme needed to break down certain substances. These substances can build up in the body, causing enlarged organs, abnormal bone structure, changes in facial features, breathing problems, heart problems, vision or hearing loss, and changes in mental or physical abilities.
Laronidase may improve breathing and walking ability in people with this condition. However, this medication is not a cure for MPS I.
Laronidase may also be used for purposes not listed in this medication guide.
Warnings
An allergic reaction may occur during or shortly after infusion of laronidase. Tell your caregivers or get emergency medical help right away if you have any signs of a severe allergic reaction, such as sweating, chest discomfort, trouble breathing, pale skin, blue lips or fingernails, and feeling like you might pass out.
Before taking this medicine
Your laronidase infusion may be delayed if you have a fever or cold symptoms.
Tell your doctor if you have ever had:
breathing problems;
heart disease; or
sleep apnea, and you use a continuous positive airway pressure (CPAP) machine.
Tell your doctor if you are pregnant or breastfeeding.
It is not known whether laronidase will harm an unborn baby. However, MPS symptoms can get worse during pregnancy and may cause medical problems in both mother and baby. The benefit of treating MPS may outweigh any risks to the baby.
Your name may need to be listed on an MPS I Registry while you are using this medicine. The purpose of this registry is to track the progression of this disorder and the effects that laronidase has on long-term treatment of MPS I. The registry also tracks the effects of laronidase on a baby if you are pregnant or breastfeeding.
How is laronidase given?
Laronidase is given as an infusion into a vein. A healthcare provider will give you this injection.
Laronidase is usually given once per week.
Tell your doctor if you have been sick with a fever or ...
