Larotrectinib
Generic name: larotrectinib [ LAR-oh-TREK-ti-nib ]
Brand name: Vitrakvi
Dosage forms: oral capsule (100 mg; 25 mg); oral solution (20 mg/mL)
Drug class:Multikinase inhibitors
What is larotrectinib?
Larotrectinib is used to treat certain tumors that are caused by an abnormal "NTRK" gene. Larotrectinib is used when the cancer has spread to other parts of the body or cannot be removed with surgery or other cancer treatments.
Larotrectinib is sometimes given after other cancer treatments did not work or have stopped working.
Larotrectinib was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to larotrectinib, but further studies are needed.
Larotrectinib may also be used for purposes not listed in this medication guide.
Warnings
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Before taking this medicine
Tell your doctor if you have ever had:
liver disease; or
nerve problems.
You may need to have a negative pregnancy test before starting this treatment.
Both men and women using larotrectinib should use effective birth control to prevent pregnancy. Larotrectinib can harm an unborn baby or cause birth defects if the mother or father is using this medicine. Keep using birth control for at least 1 week after your last dose.
This medicine may affect fertility (ability to have children) in women. However, it is important to use birth control to prevent pregnancy because larotrectinib can harm an unborn baby.
Do not breast-feed while using this medicine, and for at least 1 week after your last dose.
How should I take larotrectinib?
Your doctor will perform a test to make sure larotrectinib is the right treatment for your type of tumor.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Take this medicine with a full glass of water.
You may take larotrectinib with or without food.
Swallow the capsule whole and do not crush, chew, break, or open it.
Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
You will need frequent medical tests t...
